Mechanism of Inhibitory Synapse Formation Regulated by Synaptic Protein MDGA1 (image) DGIST (Daegu Gyeongbuk Institute of Science and Technology) Share Print E-Mail Caption Neurexins (orange) at the presynapse and Neuroligin at the postsynapse mediate synaptic development by binding two neurons through interactions. In inhibitory synapses, the regulatory protein MDGA1 produces a Neuroligin-2 (NL2) / MDGA1 complex based on strong binding power to Neuroligin-2 / Neurexin and effectively inhibits the development of inhibitory synapse by selectively interferes with binding of Neuroligin-2/Neurexin. Credit DGIST Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.