Treatment with a neuroprotective compound that saves brain cells from dying also prevents the development of depression-like behavior and the later onset of memory and learning problems in a rat model of Alzheimer's disease. The image shows brain tissue from Alzheimer's rats that were untreated (left) or treated (right) with the neuroprotective compound. The white "holes" indicated by the arrows are areas of brain cell death, and are more numerous in the untreated rats. Although the treatment protects the animals from neuronal cell death and Alzheimer's-type symptoms, it does not alter the buildup of amyloid plaques and neurofibrillary tangles in the rat brains. The research from the Iowa Neuroscience Institute at the University of Iowa was published online in the journal Biological Psychiatry.