Mutation Signatures, by Age, Location and Disease Status (image) Boston Children's Hospital Share Print E-Mail Caption In these graphs, the number of mutations per neuron are grouped by age for each mutation category (similar ages are grouped by color). The circles represent individual neurons from the normal prefrontal cortex (PFC); triangles represent the normal dentate gyrus; diamonds denote neurons from people with neurodegenerative disease: Cockayne syndrome (CS) or xeroderma pigmentosa (XP). Signature A strongly correlates with age, regardless of disease status or brain region, while Signatures B and C do not. Credit Reprinted with permission from MA Lodato et al., Science Dec. 7, 2017, DOI: 10.1101/221960 Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.