Amity Manning andConor Herlihy, Worcester Polytechnic Institute (image) Worcester Polytechnic Institute Share Print E-Mail Caption Amity Manning, left, assistant professor of biology and biotechnology at Worcester Polytechnic Institute (WPI), and Conor Herlihy, a PhD candidate in biology and biotechnology, review images of cells undergoing mitosis in the absence of the protein pRB, which she has shown plays a critical role in assuring that the chromosomes are correctly segregated when a cell divides. The cells have been engineered to express fluorescently labelled proteins, which make the chromatin (the complex of proteins and genetic material that make up chromosomes) appear blue and the microtubules (the structure that actually separates the chromosomes) appear red. Manning's team is exploring how errors in chromosome segregation in cancer cells in the absence of pRB may contribute to genetic variability and chemotherapy resistance in tumors. Credit Worcester Polytechnic Institute (WPI) Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.