Figure Proposed mMdel for HGU Regulation (image) Kanazawa University Share Print E-Mail Caption Proposed model for HGU regulation by Sirt2. NAD+/Sirt2 deacetylates K126 of GKRP, an inhibitor protein of glucokinase, thereby inducing glucose-dependent GKRP dissociation from glucokinase and enhancing HGU. However, in obesity and diabetes, impeded NAD+/Sirt2-dependent GKRP deacetylation inhibits glucokinase-GKRP dissociation and reduces HGU. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.