Molecular Models of the Lung Cancer Drug Osimertinib In Complex With Egfr (image) University of Bristol Share Print E-Mail Caption Molecular models of the lung cancer drug osimertinib in complex with EGFR. On the left, osimertinib assumes a conformation that allows it to react with Cys797 leading to the effective inhibition of the enzyme and to cancer cell death. On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive. Credit University of Bristol Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.