Formation of Collagen IV Trimer and Its Monitoring System (image) Kumamoto University Share Print E-Mail Caption (A) Collagen IV alpha-3, alpha-4, and alpha-5 normally form complexes (trimers) and become constituents of the basement membrane in the kidney. In Alport Syndrome, genetic mutation in one of the chains disrupts trimer formation. (B) By fusing collagen chains to Nanoluciferase fragments, it is possible to assess trimer formation of alpha-3, alpha-4, and alpha-5 by luminescence intensity. Credit Dr. Kohei Omachi Usage Restrictions These images may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.