Evaluation of the Clinically Reported Mutation of the Alpha-5 Chain during Trimer Formation (image) Kumamoto University Share Print E-Mail Caption (A) Expression of collagen IV alpha-3, alpha-4, and alpha-5 in cells. High luminescence was produced only in the formation of the alpha-345 trimer. (B) Mutant alpha-5 proteins reported in Alport Syndrome had a trimer formation lower than that of the normal type (WT). This suggests that we can evaluate functional abnormalities of collagen IV found in Alport Syndrome using this assay system. Credit Dr. Kohei Omachi Usage Restrictions These images may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.