a) single cells (CTCs and WBCs) from a patient affected by prostate cancer; cluster A represents 6 CTCs with small or no differences in copy number profiles; cluster B is formed by WBCs clustering, as expected, on a distinct branch of the tree. b,c) single cells (CTCs and WBCs) from 2 patients affected by lung adenocarcinoma. Values are expressed as fold changes respect to the main ploidy.
Fig. 8 Ferrarini A, Forcato C, Buson G, Tononi P, del Monaco V, Terracciano M, et al. (2018) A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products. PLoS ONE 13(3): e0193689. https://doi.org/10.1371/journal.pone.0193689
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