Fig.1 Osteoblastic Bone Metastasis Induced by Cancer-secreted MicroRNAs (image) Tokyo Medical and Dental University Share Print E-Mail Caption In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype. MicroRNAs are transferred between cells via exosomes and influence the phenotypes of their recipient cells. The present study demonstrated that cancer-secreted microRNAs induced osteoblastic bone metastasis through promoting the osteogenic differentiation of bone-forming cells. Credit Department of Physiology and Cell Biology,TMDU Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.