Stereotypic self-injurious behavior (SIB) induced by disruption of activity in the entopeduncular nucleus (EP). (A) Experimental paradigm. Saline or muscimol was injected into EP bilaterally. EP injection was performed 10 days after surgery, following 3 days of habituation. i.ep., EP injection. (B) Schematic diagram and example photos of SIB rats, showing wounds on chest (1), forepaws (2), belly (3), legs (4), hindpaws (5) and tail (6).