Map7/7D1 and Ens Show Planar-polarized Distribution in Epithelial Cells Forming PCP (image) Kumamoto University Share Print E-Mail Caption Upper figure: The left image visualizes the cell boundary. Fluorescent protein (EGFP) was added to Ens by genome editing technology and visualized in vivo (right panel). In Drosophila, they found that Ens localized on the proximal side (P side) (arrowhead). Lower figure: (From left to right) E-Cadherin visualizes the cell boundary [O: ovary (proximal) side, U: uterus (distal) side]; Fz6 & Celsr1: Constituent molecules of the Wnt/PCP signal; Map7/7D1 & Enlarged: In the mouse oviduct epithelium, Map7/7D1 is localized on the ovary (proximal) side. This is indicated by the left side of each cell appearing whiter than the right. Credit Dr. Koji Kikuchi Adapted from Kikuchi, K., Nakamura, A., Arata, M., Shi, D., Nakagawa, M., Tanaka, T., Uemura, T., Fujimori, T., Kikuchi, A., Nakanishi, H. (2018). Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. EMBO Reports, e45471. doi:10.15252/embr.201745471 Usage Restrictions This image may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.