Affinity Switching of LEDGF/p75 Interactions (image)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)

Caption

Phosphorylation in the specific region of the LEDGF/p75 binding partners fine-tunes the interaction. In the context of mixed lineage leukemia, the negative charge increase in the protein responsible for leukemic transformation of blood cells is indispensable for the disease.

Credit

Kateřina Čermáková

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