Confocal microscopy images show a tuberculous rabbit lung necrotizing granuloma stained with Nile red (red) and DAPI (blue) to reveal lipid-laden cells. Left image: the center of the granuloma is occupied by caseum, a 'cheese-like' material that becomes increasingly acellular as necrosis progresses. The caseum is surrounded by a cellular region containing macrophages and lymphocytes. Right image: higher magnification of the cellular region of the granuloma immediately surrounding the caseum. Nile red-stained storage lipids are visible in caseum and in the surrounding foam cells.
Riccardo Arrigucci, Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
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