How Damaging Immune Cells Develop during Tuberculosis (image) PLOS Share Print E-Mail Caption Confocal microscopy images show a tuberculous rabbit lung necrotizing granuloma stained with Nile red (red) and DAPI (blue) to reveal lipid-laden cells. Left image: the center of the granuloma is occupied by caseum, a 'cheese-like' material that becomes increasingly acellular as necrosis progresses. The caseum is surrounded by a cellular region containing macrophages and lymphocytes. Right image: higher magnification of the cellular region of the granuloma immediately surrounding the caseum. Nile red-stained storage lipids are visible in caseum and in the surrounding foam cells. Credit Riccardo Arrigucci, Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA. Usage Restrictions All figures and photographic images will be published under a Creative Commons Attribution License (CCAL), which allows them to be freely used, distributed, and built upon as long as proper attribution is given. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.