Cell Sorting Improves Cell Replacement Therapy For Parkinson's (image) American Society for Biochemistry and Molecular Biology Share Print E-Mail Caption A recent article in Molecular & Cellular Proteomics describes using new cell-surface markers to isolate a homogeneous mixture of dopamine precursor cells. The protocol may improve cell replacement therapy for Parkinson's disease. In this figure from the paper, the authors show that neurons induced from pluripotent cells that have been selected for expression of the newly described dopaminergic cell surface marker contactin 2 (top row) are more likely to express TH, an enzyme involved in dopamine production, and the dopamine transporter DAT, than unsorted cells (bottom row). Reducing the number of non-dopaminergic neurons and neural progenitors in a transplant improved recovery in a rat model and is expected to reduce side effects in patients with Parkinson's. Credit Fathi et al. Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.