When neurons get the blues. This artistic image shows neurons derived from pluripotent stem cells of antidepressant (SSRI) resistant depressed patients. SSRI-resistant patient neurons display hyperactivity in response to serotonin. The study reveals potential mechanism associated with SSRI-resistance in major depressive disorder (MDD). The image is modified from Figure 2c of Vadodaria et al., Molecular Psychiatry, 2019.