Inflammatory Changes Involving Brain, Artery (image) NIH/National Heart, Lung and Blood Institute Share Print E-Mail Caption This image shows how sleep fragmentation can decrease the brain's production of the hormone hypocretin, causing a cascade of inflammatory changes in the bone marrow that over time can damage the blood vessels and lead to the development of atherosclerosis. Credit Filip Swirski, Ph.D., Harvard Medical School. Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.