Figure (image) Kanazawa University Share Print E-Mail Caption Upper panel: MTHFD2 is abundantly expressed in the mitochondria in cancer cells. Active MTHFD2-mediated one-carbon metabolism consumes AICAR and produces IMP and purine nucleotides for cancer cell proliferation. Reduced intracellular pool of AICAR is essential for maintenance of cancer stem-like cells and their growth. Lower panel: When MTHFD2 expression is inhibited, cancer cell proliferation is inhibited due to reduced production of IMP and purine nucleotides and cancer stem-like cells are reduced due to increase levels of AICAR. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.