BMI Affects Course of Multiple Sclerosis (image) Advanced Science Research Center, GC/CUNY Share Print E-Mail Caption Being overweight and obese worsens the disease course in multiple sclerosis patients. Specific fats, called ceramides (yellow), are more abundant in the blood of patients with high BMI (left image), compared to those with normal BMI (right image). Ceramides in high-BMI patients enter inside the nucleus of monocytes (purple) where they change the way the genetic information is read by the cells, making them proliferate. The increased number of monocytes can travel back to the brain and cause more damage. Credit Casaccia Lab Usage Restrictions Use only in conjunction with this study Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.