Image1: Strong Chewing Modulates Igf-1 Expression in Osteocytes for the Jawbone Reconstruction (image) Tokyo Medical and Dental University Share Print E-Mail Caption a. Superimposition of the jawbone images acquired by the computer simulation. Blue: before remodeling and red: after remodeling. Left: coronal section and right: lateral projection. The dotted circle indicates the extrusion of the bone. The blue and the red lines denote the mandibular height. b. Distribution of the mechanical stress in the jawbone, before and after remodeling under the increased mastication. c. Superimposition of the images of the jawbone of mice fed with the HD or ND. Blue: ND and red: HD. The dotted circle indicates the extrusion of the bone. The blue and the red lines denote the mandibular height. d. Immunohistological images of the jawbone of mice fed with the HD or ND. IGF-1 (red); and nuclei (blue). The dotted lines indicate the jawbone surface. Arrows indicates the osteocytes expressing IGF-1. e. Graphical abstract. In order to consume harder foods, masticatory muscles generate stronger force that induces mechanical stress in the jawbone. The stress stimulates osteocytes to produce IGF-1. The upregulated IGF-1 enhances osteoblastogenesis to reconstruct the jawbone morphology so that it endures the loaded force. Credit Department of Cell Signaling,TMDU Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.