PCNA Cycling during DNA replication (image) Institute for Basic Science Share Print E-Mail Caption PCNA loading by RFC marks initiation of DNA synthesis. ATAD5-RLC functions as a universal PCNA sweeper that is essential for the termination of DNA replication and repair. Credit IBS Usage Restrictions Please indicate IBS as the credit holder. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.