Figure 2 (image) Kanazawa University Share Print E-Mail Caption The pathway whereby RB controls CCL2. Loss of RB increases fatty acid oxidation (FAO) by activating AMP-activated protein kinase (AMPK) leading to inactivation of Acetyl-CoA carboxylase (ACC) which suppresses FAO. This promotes mitochondrial superoxide production and JNK activation which enhances CCL2 expression. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.