DART Nanoparticles (image)

University of Maryland School of Medicine

Caption

An illustration of the DART nanoparticle (NP) containing the chemotherapy drug paclitaxel is shown. The NP surface is coated with polyethylene glycol (PEG) to reduce clearance from the bloodstream; after reaching the tumor, the PEG coating promotes spreading within tumor tissue. DART NPs are also coated with ITEM 4, a monoclonal antibody that targets Fn14, a cell surface receptor commonly overexpressed on cancer cells. The image on the right is a transmission electron microscope (EM) picture of purified DART NPs.

Credit

University of Maryland School of Medicine

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