Hyperactive Immune System Gene Causes Schizophrenia-like Changes in Mice (image) PLOS Share Print E-Mail Caption Overactivation of the neuroimmune gene C4 leads to microglia-mediated engulfment of synapses in the medial prefrontal cortex. This image was taken by Rhushikesh A. Phadke using confocal microscopy. Magenta: microglia (Iba1). Cyan: synapses (PSD95). Yellow: microglia lysosomes (CD68). Credit Rhushikesh A. Phadke Usage Restrictions CC-BY: Redistribution allowed with credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.