Brain Reward Circuit (image) NIH/National Institute of Mental Health Share Print E-Mail Caption The transcription factor deltaFosB mediates resilience in the nucleus accumbens, hub of the brain's reward circuit. It is the target of an intensive high tech screening for small molecules that tweak it, which could lead to a new class of resilience-boosting antidepressants. Credit Eric Nestler, M.D., Mount Sinai School of Medicine Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.