A model illustrating the Thbs1/integrin/YAP signaling pathway in remodeling of vessel walls.
Cyclic stretch induces secretion of Thbs1, which binds to integrin αvβ1 and aids in the maturation of FA-actin complex, thereby mediating nuclear shuttling of YAP via inactivation of Rap2 and Hippo pathway.
In vivo, Thbs1/integrins/YAP signaling may lead to maturation of FA after TAC-induced pressure overload to protect the aortic wall. In contrast, Thbs1/integrins/YAP signaling leads to neointima (NI) formation upon flow cessation by carotid artery ligation. ECs: endothelial cells, SMCs: smooth muscle cells, EL: elastic lamella, LCA: left carotid artery.