Left, Age-related change in the venous drainage pattern (i.e., timing dissociation between the superficial and deep venous systems, yellow dots). Pink dots represent the data from patients with traumatic brain injury. The pattern reveals an interaction between disease effect and age. Right, Three-dimensional rendering of the brain region presenting an upstream shift with age (yellow) located under the lateral ventricles (white). Major components of the cerebral venous system are shown in blue.
(Curves in the background illustrate the low-frequency perfusion lag structure in the MRI signal upon which the new aging marker is based.)