Docking interface between the modified 80R antibody and the RBD of the SARS-CoV-2 spike protein. The model shows the structural interface with the 80R antibody above and the RBD below. The seven substitutions in 80R are shown in magenta and RBD residues are shown in cyan. Notice how the substitutions in 80R allow new aromatic-aromatic interactions that improve binding to the RBD and are not present in wild type 80R. E484 is shown pointing towards the beta strand of 80R and a glycine substitution was therefore introduced to avoid clashes.