An illustration of how a mutation to MARK4 causes Alzheimer's disease. (image) Tokyo Metropolitan University Share Print E-Mail Caption The mutant MARK4 creates a form of tau which accumulates easily in brain cells, causing neurons to die. Credit Tokyo Metropolitan University Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.