Metabolic shunting and OSMAC for the biosynthesis of rubratoxins in fungus Penicillium dangeardii (image)

Compuscript Ltd

Caption

A combinational genome mining strategy based on metabolic shunting and OSMAC by deleting the key gene (rbtJ) for the biosynthesis of main products rubratoxins in fungus Penicillium dangeardii successfully aroused abundant silent gene clusters and led to the production of numerous novel metabolites with unprecedented structures and diverse bioactivities.

Credit

Acta Pharmaceutica Sinica B

Usage Restrictions

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