a, PE rates at endogenous on-target and off-target sites. b, Experimental design and work flow of whole-genome sequencing. c, d, Numbers of SNVs (c) and Indels (d) identified by WGS in the control, PE and base editor (BE3) groups. e, Genome-wide landscape of the distribution of telomere repeats in the Zhonghua11 genome. f, Comparison of number of reads with more than five TRs per million raw reads in the WT, AGL1, control, PE and BE3 groups. g, Comparison of the percentages of reads in the Cas9 and HPT coding regions versus in the whole T-DNA fragment.