Soapy Drug Delivery to Cancer Cells (3 of 7) (video) American Association for the Advancement of Science Share Print E-Mail Loading video... Caption This animation explains the accumulation of conventional anticancer drugs and polymeric micelles in normal and cancerous tissues. The conventional anticancer drugs penetrate the vascular wall and therefore accumulate in both normal and cancerous tissues. Such non-specific accumulation results in limited drug efficacy and occurrence of side effects. In contrast, polymeric micelles cannot penetrate the vascular wall and they only pass through leaky tumor vasculature. Note that tumor vasculature possesses the pore of several tens to hundreds nanometer. Therefore, polymeric micelles can selectively accumulate in solid tumors, achieving enhanced drug efficacy without side effects. This video relates to an article that appeared in the Jan. 5, 2011, issue of Science Translational Medicine, published by AAAS. The study, by Mami Murakami of the University of Tokyo in Tokyo, Japan, and colleagues was titled, "Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting." Credit [Video file © Science/AAAS] Usage Restrictions Please cite the owner of the video when publishing. This video may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.