Cleft FGF Image (image) University of Iowa Share Print E-Mail Caption University of Iowa researchers have discovered that mutations in FGF signaling pathway genes contribute to cleft lip and palate. The top figure shows the normal sequence for a region of the FGFR1 gene; the bottom figure shows a mutation in the same region for a person with cleft lip and palate. Credit University of Iowa, Jeff Murray Lab/Bridget Riley Usage Restrictions Must be used with credit line. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.