A Pap Smear for Ovarian Cancer? (1 of 3) (image) American Association for the Advancement of Science Share Print E-Mail Caption Schematic demonstrating the principal steps of the procedure described in this study. Tumor cells shed from ovarian or endometrial cancers are carried into the endocervical canal. These cells can be captured by the brush used for performing a routine Pap smear. The brush contents are transferred into a liquid fixative, from which DNA is isolated. By means of massively parallel sequencing, this DNA is queried for mutations that indicate the presence of a malignancy in the female reproductive tract. This image relates to a paper that appeared in the Jan. 9, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by I. Kinde at Johns Hopkins Kimmel Cancer Center in Baltimore, Md., and colleagues was titled, "Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers." Credit Image courtesy of Elizabeth Cook Usage Restrictions Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.