How the Anticancer Drug AS1411 Alters MicroRNA Levels (image) Ohio State University Wexner Medical Center Share Print E-Mail Caption The drug AS1411 works by blocking the cell's production of regulatory molecules called microRNA, some types of which are associated with cancer. Specifically, the drug inhibits a protein called nucleolin that plays a critical role in the microRNA maturation process. Left: Steps in the microRNA maturation process. Right: How AS1411 interferes with microRNA maturation. Credit The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute Usage Restrictions Please credit The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.