CD33 Over-Expressed or Inactivated and Beta-Amyloid (image) NIH/National Institute of Mental Health Share Print E-Mail Caption Little beta-amyloid can be seen in microglia of a mouse line in which CD33 is over-expressed (C"), compared to microglia of mice in which CD33 is experimentally inactivated (D"). Evidence from post-mortem human brains indicates that CD33 is similarly over-active in Alzheimer's disease, suggesting that a treatment that impedes it might help treat or prevent the disease. Credit Rudolph Tanzi, Ph.D., of Massachusetts General Hospital and Harvard University Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.