Modeling Sickle Cell Bloodflow (video) Brown University Share Print E-Mail Loading video... Caption Researchers from Brown University used computer models to show how different types of red blood cells interact to cause sickle cell crisis, a painful blockage of blood flow in capillaries. The models showed that sticky SS2 cells (blue) start the process by getting stuck on blood vessel walls. Rigid, crescent-shaped cells (red) that are the hallmark of the disease then get stuck behind the SS2 cells. This is the first time a biophysical mechanism behind sickle cell disease has been identified. Credit Karniadakis Lab / Brown University Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.