The Immune System Doesn't Need You, TLR4 (2 of 2) (video) American Association for the Advancement of Science Share Print E-Mail Loading video... Caption Macrophages undergo pyroptosis when cytoplasmic LPS triggers caspase-11 activation. This video relates to a paper that appeared in the 13 Sept., 2013, issue of Science, published by AAAS. The paper, by Nobuhiko Kayagaki at University of North Carolina at Chapel Hill in Chapel Hill, N.C., and colleagues was titled, "Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock." Credit [Video courtesy of Jon Hagar and Ine Jørgensen] Usage Restrictions Please cite the owner of the video when publishing. This video may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.