SUMO-1 Gene Rescues Hearts with Broken Plumbing Arms (2 of 3) (video) American Association for the Advancement of Science Share Print E-Mail Loading video... Caption Co-author Dr. Hajjar narrates this movie, a glimpse into the intracellular space of the cardiomyocyte. The movie shows how SUMO-1 attaches to SERCA2a and increases its activity, leading to faster calcium uptake. This in turn allows faster calcium entry into the sarcoplasmic reticulum. This image relates to a paper that appeared in the November 13, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. L. Tilemann at Icahn School of Medicine at Mount Sinai in New York, N.Y., and colleagues was titled, "SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure." Credit Video courtey of Roger J. Hajjar, MD Usage Restrictions Please cite the owner of the video when publishing. This video may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.