Manganese Transport and Role in Providing Nucleotide Building Blocks for DNA (image) Virginia Commonwealth University Share Print E-Mail Caption This image is an overview of manganese transport and role in providing nucleotide building blocks for DNA. The red, blue and brown shapes are components of the complex that transports manganese into the bacterial cell. NrdEF is the ribonucleotide reductase enzyme that creates the nucleotides and NrdI is the protein required for attaching manganese to the enzyme. Elimination of either NrdEF or NrdI completely prevented Streptococcus sanguinis from causing infective endocarditis. Credit Figure courtesy of Todd Kitten, Ph.D.,/ VCU. Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.