Proof of Principle: Gut Diagnostic (image) Wyss Institute for Biologically Inspired Engineering at Harvard Share Print E-Mail Caption Inspired by Nature, the team engineered E. coli to sense, record and remember an environmental signal in the gut -- and also demonstrated that they can survive and function within complex environments such as the mammalian gut. This work lays the foundation for the use of engineered probiotic bacteria that serve as living diagnostics. In this schematic engineered probiotic E. coli have colonized the mammalian intestine and "remember" exposure to an environmental signal, which is indicated by the cells turning blue in color. Credit Jonathan Kotula, Harvard's Wyss Institute and Harvard Medical School Usage Restrictions Credit: Jonathan Kotula, Harvard's Wyss Institute and Harvard Medical School Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.