Amyloid-beta and Tau in Mouse Hippocamopus (image) University of Pennsylvania School of Medicine Share Print E-Mail Caption Amyloid-beta (antibody 12F4) and hyper-phosphorylated tau (antibody AT180) immunostaining of hippocampus from 18-month-old mice. Amyloid plaques (top row) and intracellular tau tangles (bottom row) in the 3xTg mouse were strongly reduced by genetic deletion of 50 percent of the IP3R1 in the 3xTg/Opt mouse. Wild-type (WT) and Opt mice expressing 50 percent of InsP3R exhibited no pathology. Credit J. Kevin Foskett, Ph.D., & Dustin Shilling; Perelman School of Medicine at the University of Pennsylvania Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.