Neuron Hyperactivation in the Brain Leads to Depression (image) Cold Spring Harbor Laboratory Share Print E-Mail Caption Researchers at Cold Spring Harbor Laboratory have identified the neurons in the brain that determine if a mouse will learn to cope with stress or become depressed. These neurons, located in a region of the brain known as the medial prefrontal cortex (green, top image), become hyperactive in depressed mice (bottom panel is close-up of above, yellow indicates activation). The team showed that this enhanced activity in fact causes depression. Credit Bo Li/ Cold Spring Harbor Laboratory Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.