(A) This is an axial T2 magnetic resonance imaging (MRI) image showing an acute stroke in the left lateral prefrontal cortex. (B) This is a coronal neuropathological specimen of an infarct in the left lateral PFC (note the hemorrhagic conversion in the cortical mantle). The red dashed line on the MRI in (A) shows the approximate site of the postmortem coronal slice. (C) This is an axial T1 MRI image showing infiltrating glioblastoma in the right lateral frontal cortex. (D) This is a postmortem axial slice of an infiltrating glioblastoma in the right lateral frontal lobe. Neuropathological specimen in (B) compliments of Professor Dimitri Agamanolis, Akron Children's Hospital.