LGI1 Localization (image) National Institutes of Natural Sciences Share Print E-Mail Caption Wild-type LGI1 is localized in the molecular layer of the hippocampus where synapses are formed (left), whereas mutant LGI1 is rapidly degraded within the cell body and is not transported to the synapse due to the mutation which causes the conformational defect of LGI1. Credit © National Institutes of Natural Sciences Usage Restrictions The image may only be used with appropriate credit. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.