Amyloid beta oligomers bind to neurons and are distinct from amyloid plaques. Brain sections from an aged Alzheimer's mouse model were probed with antibodies against Abeta oligomers (568-NU4, red) and amyloid plaques (ThioS, green). Images demonstrate that Abeta oligomers (568-NU4) are often associated with, yet distinct from, amyloid plaques (ThioS). Where both amlyoid plaques (green) and A? oligomers (red) overlap shows up as yellow. NU4 labelling is more abundant than the ThioS staining. Data supports the notion that NU4 thus affords an excellent targeting antibody for the development of an amyloid beta oligomer-specific MRI probe that is distinct from currently available plaque probes.