Artistic Rendering of Blood Flow's Protective Qualities in the Heart (image) Gladstone Institutes Share Print E-Mail Caption This image shows blood flow in the heart activates the NOTCH1 gene, triggering a cascade of anti-inflammatory and anti-calcification pathways. Disruption of this process can result in a hardening of the valves in cardiovascular disease. Credit Christina Theodoris Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.