This is a composite showing reduced bile flow (A, B) and severe damage to the gallbladder (C, D) in an eight-day-old zebrafish larva that received a low dose of the isolated plant toxin biliatresone for three days and the normal gallbladder of a control zebrafish larva that did not receive the toxin. Arrows point to the damaged gall bladder. The other green structures are bile ducts in the liver. The ducts connecting the liver to the gallbladder are also affected by the toxin.
Michael Pack, M.D., Perelman School of Medicine, University of Pennsylvania.