Principle behind Spiegelmers (image) Aarhus University Share Print E-Mail Caption To the left is an illustration of the principle behind Spiegelmers. Normal aptamers are formed from D-nucleotides also used for RNA and DNA, whereas the Spiegelmers are constructed from L-nucleotides. The two molecules are therefore perfect mirror-images of each other. To the right is shown the three-dimensional structure of the Spiegelmer from the German company NOXXON Pharma AG bound to the inflammatory protein C5a determined by the scientists at Aarhus University through X-ray crystallography. Credit Laure Yatime, Aarhus University Usage Restrictions Credit to Laure Yatime, Aarhus University Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.